| S.NO | Name of Governor | Entered Office | Left Office | Political Party |
| 01 | Shaikh G.H. Hidayatullah | August 15, 1947 | October 4, 1948 | Muslim League |
| 02 | Shaikh Din Muhammad | October 7, 1948 | November 19, 1949 | Muslim League |
| 03 | Mian Aminuddin | November 19, 1949 | May 1, 1953 | Muslim League |
| 04 | George Baxandall Constantine | May 2, 1953 | August 12, 1953 | Civil Administration |
| 05 | Habib Ibrahim Rahimtoola | August 12, 1953 | June 23, 1954 | Muslim League |
| 06 | Nawab Iftikhar Hussain | June 24, 1954 | October 14, 1955 | Muslim League |
| 07 | Sindh province abolished and became part of West Pakistan unit | October 14, 1955 | July 1, 1970 | |
| 08 | Lieutenant-General Rakhman Gul, PA | July 1, 1970 | December 20, 1971 | Military Administration |
| 09 | Mumtaz Bhutto | December 24, 1971 | April 20, 1972 | Pakistan Peoples Party |
| 10 | Mir Rasool Bux Talpur | April 29, 1972 | February 14, 1973 | Pakistan Peoples Party |
| 11 | Begum Ra’ana Liaquat Ali Khan | February 15, 1973 | February 28, 1976 | Independent |
| 12 | Muhammad Dilawar Khanji | March 1, 1976 | July 5, 1977 | Pakistan Peoples Party |
| 13 | Abdul Kadir Shaikh | July 6, 1977 | September 17, 1978 | Civil Administration |
| 14 | Lieutenant-General S.M. Abbasi, PA | September 18, 1978 | April 6, 1984 | Military Administration |
| 15 | Lieutenant-General (retired) Jahan Dad Khan, PA | April 7, 1984 | January 4, 1987 | Military Administration |
| 16 | Ashraf W. Tabani | January 5, 1987 | June 23, 1988 | Pakistan Muslim League |
| 17 | General (retired) Rahimuddin Khan, PA | | | Military Administration |
| 18 | Justice Qadeeruddin Ahmed | September 12, 1988 | April 18, 1989 | Supreme Court of Pakistan |
| 19 | Justice Fakhruddin G. Ebrahim | April 19, 1989 | August 6, 1990 | Supreme Court of Pakistan |
| 20 | Mahmoud Haroon (1st term) | August 6, 1990 | July 18, 1993 | Independent |
| 21 | Hakim Said | July 19, 1993 | January 23, 1994 | Independent |
| 22 | Mahmoud Haroon (2nd term) | January 23, 1994 | May 21, 1995 | Independent |
| 23 | Kamaluddin Azfar | May 22, 1995 | March 16, 1997 | Pakistan Peoples Party |
| 24 | Lieutenant General (retired) Moinuddin Haider, PA | March 17, 1997 | June 17, 1999 | Military Administration |
| 25 | Mamnoon Hussain | June 19, 1999 | October 12, 1999 | Independent |
| 26 | Air Marshal Azim Daudpota, PAF | October 25, 1999 | May 24, 2000 | Military Administration |
| 27 | Muhammad Mian Soomro | May 25, 2000 | December 26, 2002 | Civil Administration |
| 28 | Ishrat-ul-Ibad Khan | December 27, 2002 | 9 November 2016 | Muttahida Qaumi Movement(MQM) |
| 29 | Saeed uz zaman Siddiqui | 9 November 2016 | | |
| 30 | Muhammad Zubair | | | |
| 31 | Imran Ismail | 2018 | To date | Pakistan Tehreek-e-Insaf |
